what's the matter?

what's the matter?

What's wrong?

What's the trouble?

What happened?

What's up?

1. What's the matter

What's the matter with you?

= What's the trouble with you?

= What's wrong with you?

2 ?with?

What's the matter with sb.?

= What's your trouble?

=What's up?

= What happens to sb.?

What?s the matter with you ?