二者區別如下：
keep off，意思：（使）不接近；禁食；（雨、雪等）沒有下；避開某壹話題；
keep out，意思：（使）留在外面；扣留；保留；留下。
擴展資料：
keep off例句：
1.Keep?off?the?lawn?[?grass]. 請勿踐踏草地。
2.Keep?off?the?subject?of?politics 勿談政治。
3.The?doctor?has?advised?him?to?keep?off?fattening?food. 醫生已建議他不要吃致肥食物。
4.Keep?off?the?grass. 勿踩草坪。
keep out例句：
1.Tell?the?children?to?keep?out?of?mischief! 告訴這些孩子不要調皮！
2.They?sandbagged?their?homes?to?keep?out?floods. 他們在房屋周圍堆沙袋以抵禦洪水的侵襲。
3.Keep?out?of?mischief. 不要頑皮。
4.She?stamped?her?feet?on?the?pavement?to?keep?out?the?cold. 她在人行道上跺著雙腳取暖