資料來源：gamefaqs，我做了簡單翻譯。各版本通用，缺少360live對戰部分，沒辦法，本人沒有360版吉他，沒試。
壹：模式菜單：
地球人都知道的就不說了，單說新增模式。
Co-Op Career：雙人合作過關，兩人可以選擇不同的難度，選擇主音和貝司或節奏吉他，***6個舞臺，比單人少了兩個，每個舞臺的返場曲目，也就是最後壹首是這個模式獨有的，過關後會自動添加到Quick Play模式裏。
Multiplayer：對戰模式，分三種。
1、Face-Off：兩人可以選擇不同的難度，輪流或交叉彈奏，得分高者獲勝，不能使用star power。
2、Pro Face-Off：兩人只能選擇同樣的難度，且都要彈滿整曲，得分高者獲勝，可以使用star power 。
3、Battle Mode：本作新增要素，樂趣滿載，本模式下會隨機得到很多陷害對人的道具，合理使用，會快速將對方ko。道具可以儲存3個，激活辦法同star power。
Broken string：某鍵失靈，快速連打解除。
Difficulty up：對方的難度會升高壹個等級，持續壹小段時間，ex難度下無效。
Amp overload：音符會閃爍，持續壹小段時間。
Whammy bar：全部音符失靈，無法彈奏，快速搖動搖棒（Whammy bar）解除。
Steal power：偷走對手的能量。
Double notes：對方的單指note變為二指，二指變為三指，持續壹小段時間。
Lefty flip：對手變成左手模式，綠鍵變為橙鍵。
Death Drain：用骷髏來遮擋對手的彈奏可視區域。
二：曲目清單：
單人模式40首，Bonus曲目25首（24首購買，最後壹首任意難度通關後出現），雙人模式下獨有的6首，***71首。以上均可以在Quick Play下自由彈奏。單人模式下另有3首battle曲目，很遺憾，無法在Quick Play下選取。
單人模式
跟2代壹樣，***8個舞臺，多了3場battle戰，只有打敗對方，才能進入返場曲目，slash亂入，戰之，let's rock!
1. Starting Out Small
* "Slow Ride" – Foghat
* "Talk Dirty to Me" – Poison
* "Hit Me with Your Best Shot" – Pat Benatar
* "Story of My Life" – Social Distortion
* "Rock and Roll All Nite" – Kiss (Encore)
2. Your First Real Gig
* "Mississippi Queen" – Mountain
* "School's Out" – Alice Cooper
* "Sunshine of Your Love" – Cream
* "Barracuda" – Heart
* "Guitar Battle vs. Tom Morello"（鳥人為Rage Against the Machine樂隊的吉他手，長得磕噌了點）
* "Bulls on Parade" – Rage Against the Machine (Encore)
3. Making the Video
* "When You Were Young" – The Killers
* "Miss Murder" – AFI
* "The Seeker" – The Who
* "Lay Down" – Priestess
* "Paint It, Black" – The Rolling Stones (Encore)
4. European Invasion
* "Paranoid" – Black Sabbath
* "Anarchy in the U.K." – Sex Pistols
* "Kool Thing" – Sonic Youth
* "My Name Is Jonas" – Weezer
* "Even Flow" – Pearl Jam (Encore)
5. Bighouse Blues
* "Holiday In Cambodia" – Dead Kennedys
* "Rock You Like a Hurricane" – Scorpions
* "Same Old Song and Dance" – Aerosmith
* "La Grange" – ZZ Top
* "Guitar Battle vs. Slash "（槍花的吉他手，遊戲封面人物）
* "Welcome to the Jungle" – Guns N' Roses (Encore)
6. The Hottest Band on Earth
* "Black Magic Woman" – Santana
* "Cherub Rock" – The Smashing Pumpkins
* "Black Sunshine" – White Zombie
* "The Metal" – Tenacious D
* "Pride and Joy" – Stevie Ray Vaughan (Encore)
7. Live in Japan
* "Before I Forget" – Slipknot
* "Stricken" – Disturbed
* "3's & 7's" – Queens of the Stone Age
* "Knights of Cydonia" – Muse
* "Cult of Personality" – Living Colour (Encore)
8. Battle For Your Soul
* "Raining Blood" - Slayer
* "Cliffs of Dover" – Eric Johnson
* "The Number of the Beast" – Iron Maiden
* "One" – Metallica
* "Guitar Battle vs. Lou" (來自The Devil Went Down to Georgia –
Charlie Daniels Band)
Co-Op Career
雙人合作模式
1. Getting a Band Together
* "Barracuda" – Heart
* "When You Were Young" – The Killers
* "Bulls on Parade" – Rage Against the Machine
* "Slow Ride" – Foghat
* "Sabotage" – Beastie Boys (Encore) 該模式獨有
2. We Just Wanna Be Famous
* "School's Out" – Alice Cooper
* "Kool Thing" – Sonic Youth
* "Miss Murder" – AFI
* "The Seeker" – The Who
* "Reptilia" – The Strokes (Encore) 該模式獨有
3. Overnight Success
* "Paranoid" – Black Sabbath
* "Welcome to the Jungle" – Guns N' Roses
* "Anarchy in the U.K." – Sex Pistols
* "Lay Down" – Priestess
* "Suck My Kiss" – Red Hot Chili Peppers (Encore)該模式獨有
4. Getting the Band Back Together
* "Holiday in Cambodia" – Dead Kennedys
* "Black Magic Woman" – Santana
* "Same Old Song and Dance" – Aerosmith
* "Cherub Rock" – The Smashing Pumpkins
* "Cities on Flame With Rock and Roll" – Blue ?yster Cult (Encore)該模式獨有
5. Jailhouse Rock
* "My Name Is Jonas" – Weezer
* "Black Sunshine" – White Zombie
* "3's & 7's" – Queens of the Stone Age
* "The Metal" – Tenacious D
* "Helicopter" – Bloc Party (Encore)該模式獨有
6. Battle For Your Souls...
* "Knights of Cydonia" – Muse
* "One" – Metallica
* "The Number of the Beast" – Iron Maiden
* "Cult of Personality" – Living Colour
* "Monsters" – Matchbook Romance (Encore)該模式獨有
Bonus tracks (商店購買曲目，按藍鍵切換，按黃鍵切回單人曲目)
* "Avalancha" – Héroes del Silencio
* "Can't Be Saved" – Senses Fail
* "Closer" – Lacuna Coil
* "Don't Hold Back" – The Sleeping
* "Down 'N Dirty" – LA Slum Lords
* "F.C.P.R.E.M.I.X." – The Fall of Troy
* "Generation Rock" – Revolverheld
* "Go That Far" – Bret Michaels Band
* "Hier Kommt Alex" – Die Toten Hosen
* "I'm in the Band" – The Hellacopters
* "Impulse" - An Endless Sporadic
* "In the Belly of a Shark" – Gallows
* "In Love" – Scouts of St. Sebastian
* "Mauvais Gar?on" – Naast
* "Metal Heavy Lady" – Lions
* "Minus Celsius" – Backyard Babies
* "My Curse" – Killswitch Engage
* "Nothing for Me Here" – Dope
* "Prayer of the Refugee" – Rise Against
* "Radio Song" – Superbus
* "Ruby" – Kaiser Chiefs
* "She Bangs the Drums" – The Stone Roses
* "Take This Life" – In Flames
* "The Way It Ends" – Prototype
* "Through The Fire And Flames" – DragonForce
(任意難度通關後出現，詞曲應為3代最難曲目，不怕死的去挑戰ex難度吧)
三：cheats
Options -> Cheats -> Enter New Cheat，跟前兩作不同，除了左手按鍵之外，右手還要將其彈奏出來，成功後會有提示。GRYBO分別對應綠紅黃藍橙。
***有7個cheat，目前已知的有個5個，分別是
Air Guitar：(YB) (GY) (GY) (RB) (RB) (RY) (RY) (YB) (GY) (GY) (RB) (RB) (RY) (RY) (GY) (GY) (RY) (RY)
Hyperspeed：高速模式，如果覺得自己怎麽彈都過不去了，那就試試這個，雖然號稱高速，但曲子速度並沒變化，只是卷軸的速度加快，note之間的距離拉長，反而有利反應，3代的高速分5級，選擇合適自己的。OBOYOBOY
Performance Mode：表演模式，天殺的模式，曲譜不可見，完全靠背版和對曲子的熟悉程度了，沒有人會無聊到去挑戰這個吧。(GR)(GR)(GR)(RY)(RY)(RB)(RB)(YB)(YO)(YO)(GR)(GR)(GR)(RY)(RY)(RB)(RB)(YB)(YO)(YO)
Precision Mode：精確模式，本作新增，對按鍵和彈奏精確度的判定非常嚴格，有信心的去挑戰吧。(GR)(GR)(GR)(RY)(RY)(RB)(RB)(YB)(YO)(YO)(GR)(GR)(GR)(RY)(RY)(RB)(RB)(YB)(YO)(YO)
Unlock All Songs：解除所有歌曲，找不到人合作的玩家有福了，可以憑此解鎖雙人模式下的獨有曲目。YO)(RB)(RO)(GB)(RY)(YO)(RY)(RB)(GY)(GY)(YB)(YB)(YO)(YO)(YB)、Y、R、(RY)、R、Y、O