full of 是形容詞性的詞組，可與聯系動詞 be、become 等搭配形成“系表結構”，也可用於名詞之後作後置定語或補足語。fill with 則是動詞+介詞的詞組，fill 既可用作及物動詞，也可用作不及物動詞。在詞義上，full of 表達的是“充滿了的”、“富有的”現象，而 fill with 則表達的是註入性的“充滿”行為和動作。例句：
These kids are full of energy.
I taught a group of students full of imaginations.
He filled the glass with milk.
The basement is filling with water.