Johnsy and Sue are artists who move into Greenwich Village in New York City. As Winter approaches and the weather gets colder, Johnsy becomes ill with pneumonia. She gets so sick that she believes that when the last leaf falls from the vine outside her window, she will die. An old artist, named Behrman, who lives in the same building as the girls, braves a storm one night to paint a leaf on the wall — a leaf that will never fall. Cold and wet from painting in the icy rain, he catches pneumonia and dies. This gives Johnsy the hope to survive her illness, and it also creates the masterpiece Behrman had always dreamed of painting.